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1987年2月8日至4月1日在美国旧金山总医院对15例大于18岁已确诊为早期卡氏肺孢子虫肺炎的艾滋病患者用戊双脒气化法进行治疗。将600mg戊双脒羟乙基磺酸盐溶于6ml无菌水中,放入特殊装置的喷雾器内,用压缩的氧气作为喷雾器的动力。病人每天自喷雾器内吸气体20分钟,共治疗21天。治疗后均有3ml液体遗留在喷雾器内,病人吸入药物的总量约为3mg。在疗程中每天对患者进行一次常规和肺活量检查,每隔3天测量一次血细胞、血小板、电解质、葡萄糖、肌酐、肝功能和血清中戊双脒的浓度、每周做一次胸透、动脉中氧含量检查和尿分析。经治疗无效者改用静脉注射甲氧苄啶-磺胺甲噁唑。
From February 8 to April 1, 1987, 15 patients with AIDS that had been diagnosed with Pneumocystis carinii pneumonia at the age of 18 or older at the San Francisco General Hospital in the United States were treated with pentamidine vaporization. 600 mg of pentamidine isethionate was dissolved in 6 ml of sterile water, placed in a special device sprayer, and compressed oxygen was used as the power of the sprayer. The patient inhaled gas from the sprayer for 20 minutes a day for a total of 21 days. After treatment, 3ml of liquid was left in the nebulizer, and the total amount of drug inhaled by the patient was about 3mg. The patients were given daily routine and spirometry examinations every day during the course of treatment. Blood cells, platelets, electrolytes, glucose, creatinine, liver function and serum pentamidine concentrations were measured every 3 days. Chest thoracotomy, arterial oxygenation Content check and urinalysis. The treatment was ineffective switch to intravenous trimethoprim - sulfamethoxazole.