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应用苯妥英钠(DPH)治疗癫痫过程中引起肝脏毒副作用颇为罕见,作者等报道一例如下。患者64岁,黑人女性,一月前在外院作脑内动脉瘤切除术后给以DPH治疗。入院前一周出现弥漫性皮疹而停用DPH,改服鲁米那。否认有肝炎、饮酒、黄疸等病史。体检:嗜睡,脱水,臀部和脸部呈弥漫性红斑疹伴有脱屑。体温101.6°F,经静脉输液后血压稳定
Application of phenytoin sodium (DPH) in the treatment of epilepsy caused by liver toxicity is quite rare, the author reported a case such as the following. The patient, 64 years old, was black and given DPH after having undergone intracranial aneurysm resection in the outpatient setting one month ago. A week before admission, diffuse rash discontinued DPH, change service Rumina. Denied hepatitis, alcohol, jaundice and other medical history. Physical examination: lethargy, dehydration, buttocks and face were diffuse erythema with scaling. Body temperature 101.6 ° F, after intravenous infusion of blood pressure stability