近年来,对肿瘤免疫机制的研究显示树突状细胞是功能最强的肿瘤抗原提呈细胞之一,连同肿瘤抗原、效应细胞如细胞毒性T淋巴细胞和自然杀伤细胞以及各种相关的细胞因子在肿瘤免疫应答过程中起着重要作用。目前以树突状细胞为基础的肿瘤疫苗研究十分流行,部分研究已经进入临床Ⅰ期阶段。本文就基于树突状细胞的肿瘤免疫的研究进展及其在口腔颌面头颈肿瘤领域的应用情况作一综述。 In recent years, studies on the mechanism of tumor immunity have shown that dendritic cells are one of the most potent tumor antigen presenting cells, along with tumor antigens, effector cells such as cytotoxic T lymphocytes and natural killer cells and various related cytokines Plays an important role in the tumor immune response process. At present, the research on dendritic cell-based tumor vaccine is very popular and some researches have entered clinical phase Ⅰ. This article reviews the progress of dendritic cell-based tumor immunity and its application in the field of oral and maxillofacial head and neck cancer.