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阿霉素７．５ｍｇ／ｋｇ一次性给大鼠静注和以肾髓质匀浆加完全弗氏佐剂造模形成大鼠慢性肾炎和慢性免疫性肾炎，肾康宁８ｇ／ｋｇ、１６ｇ／ｋｇ治疗组对阿霉素肾炎和免疫性肾炎引起的大鼠尿蛋白排出量增加、尿肌酐、血清肌酐和血清尿素氮升高有明显抑制作用（Ｐ＜０．０５ｏｒ０．０１）。病理切片可见肾康宁对阿霉素肾炎和免疫性肾炎病理变化也有明显的改善作用。
Doxorubicin (7.5 mg/kg) was intravenously administered to rats at one time and rat renal medulla homogenate plus complete Freund’s adjuvant was used to establish rat chronic nephritis and chronic immune nephritis. Shen Kangning (8 g/kg, 16 g/kg) The treatment group significantly inhibited the increase of urine protein excretion, urine creatinine, serum creatinine and serum urea nitrogen caused by adriamycin nephritis and immune nephritis (P<0.05 or 0.01). Pathological sections showed that ShenKangNing also had obvious improvement on the pathological changes of adriamycin nephritis and immunonephritis.