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肥胖性2型糖尿病组和非肥胖对照组中肿瘤坏死因子α(TNFα)基因启动子上游-857位点,CT、TT基因型频率分别为0.396、0.020和0.179、0.000,T等位基因频率分别为0.220和0.090,差异均有统计学意义(均P<0.05)。提示该位点突变与肥胖者2型糖尿病的易患性有关。
The frequencies of tumor necrosis factor α (TNFα) gene upstream -857 sites in the obese type 2 diabetes mellitus group and the non-obese control group were 0.396,0.020 and 0.179,0.000 respectively, and the frequencies of the T allele 0.220 and 0.090, the difference was statistically significant (all P <0.05). Suggesting that the site mutation and obesity in type 2 diabetes susceptibility.