论文部分内容阅读
目的 探讨小剂量肝素预防和治疗急性早幼粒细胞白血病 (AcutePremyelocyticLeukemia ,APL)联合化疗并发DIC的效果。方法 将 31例急性早幼粒细胞白血病患者分为 2组 ,Ⅰ组为联合化疗加小剂量肝素 ,Ⅱ组为单用联合化疗 ,比较两组的DIC发生率和完全缓解率。结果 肝素治疗组与对照组DIC的发生率有显著性差异 (P <0 .0 5 ) ,而完全缓解率无显著性差异 (P >0 .0 5 )。结论 治疗APL在联合化疗的基础上加用小剂量的肝素可以预防DIC的发生 ,而对完全缓解率无明显影响
Objective To investigate the effect of low-dose heparin in the prevention and treatment of acute promyelocytic leukemia (APL) combined with chemotherapy with DIC. Methods Thirty-one patients with acute promyelocytic leukemia were divided into two groups. Group I was combined chemotherapy plus low-dose heparin. Group II was treated with chemotherapy alone. The incidence of DIC and complete remission rate were compared between the two groups. Results There was a significant difference in the incidence of DIC between the heparin-treated group and the control group (P < 0.05), but there was no significant difference in the complete remission rate (P > 0.05). Conclusion Treatment of APL with combination of chemotherapy and low-dose heparin can prevent the occurrence of DIC without significant effect on the complete remission rate.