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目的 探讨遗传性乳腺癌卵巢癌(HBOC)患者所患卵巢癌的临床特点。方法 对91例HBOC患者的发病年龄、两癌发病间隔、病理类型、分期、家族史和生存期等进行分析。观察患者2 ,5年生存率,分析影响预后的因素。结果 91例HBOC患者的中位生存期为4 7个月,2 ,5年生存率分别为71 .2 %和33.5 %。卵巢癌的中位发病年龄为5 2岁,5 5岁前发病者占6 0 .4 %。在39例双原发癌中,两癌发病间隔≥6 0个月的患者2 0例,占5 1 .3%。在91例卵巢癌中,浆液性腺癌最常见,有5 4例(5 9.3%) ;Ⅲ、Ⅳ期患者70例(76 .9%) ;低分化者5 4例(5 9.3%)。结论 HBOC患者的卵巢癌发病年龄比散发者早,多数为晚期低分化,病理类型以浆液性腺癌为主,肿瘤分期和分化程度是影响患者预后的因素。对于乳腺卵巢双原发癌患者,卵巢癌的临床特点是影响其预后的主要因素。HBOC患者患卵巢癌后的中位生存期与散发性卵巢癌相似。
Objective To investigate the clinical features of ovarian cancer in hereditary breast cancer ovarian cancer (HBOC) patients. Methods The age of onset, age at onset of two cancers, pathological type, staging, family history and survival of 91 HBOC patients were analyzed. Observe the patients’ 2 and 5-year survival rates and analyze the factors influencing the prognosis. Results The median survival time of 91 HBOC patients was 47 months, and the 2 and 5 year survival rates were 71.2% and 33.5%, respectively. The median age at onset of ovarian cancer was 52 years old, with a prevalence of 60.4% before the age of 55 years. In 39 cases of double primary cancer, the incidence of two cancer ≥ 60 months in patients with 20 cases, accounting for 51.3%. In 91 cases of ovarian cancer, serous adenocarcinoma was the most common, 54 cases (59.3%); 70 cases (76.9%) in stage III and IV; 54 cases (59.3%) were poorly differentiated. Conclusions The age of onset of ovarian cancer in patients with HBOC is earlier than those in patients with dissemination, most of them are poorly differentiated in the late stage. The pathological type is mainly serous adenocarcinoma. The staging and differentiation of HBOC are the prognostic factors of patients. For breast primary ovarian cancer patients, the clinical features of ovarian cancer is the main factor affecting the prognosis. The median survival of patients with HBOC after ovarian cancer is similar to sporadic ovarian cancer.