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X线修复交叉互补基因 1(XRCC 1)是一种重要的DNA修复基因 ,参与DNA单链断裂和碱基损伤修复 ,位于人染色体 19q13 2 ,编码区单核苷酸多态位点导致相应的氨基酸改变。对其生物学特性、结构功能、基因多态与疾病易感性等方面的研究 ,可深入理解XRCC 1基因多态与环境交互作用对个体易感性的重要影响 ,其可能是某些疾病如癌症发生中潜在的易感标志物 ,对特定亚人群的筛检、预防和指导临床用药有深远意义。
XRCC1 (XRCC1) is an important DNA repair gene involved in DNA single strand breaks and base damage repair, located on human chromosome 19q13 2, coding region single nucleotide polymorphism site leading to the corresponding Amino acid changes. The biological characteristics, structural function, genetic polymorphism and disease susceptibility and other aspects of the study, can be an in-depth understanding of XRCC 1 gene polymorphisms and environmental interactions important impact on individual susceptibility, which may be some diseases such as cancer Potential markers of susceptibility to specific sub-populations of screening, prevention and guidance of clinical use of far-reaching significance.