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目的观察乌司他丁注射液对慢性阻塞性肺疾病(COPD)急性加重期并发呼吸衰竭患的肺功能的影响和临床疗效。方法选择2010年1月-2011年6月在韶关市铁路医院呼吸科诊治的慢性阻塞性肺疾病急性加重期患者80例,随机分为对照组和治疗组各40例。对照组给予常规治疗;治疗组在常规治疗基础上加乌司他丁注射液治疗,治疗10d后观察两组患者的临床疗效和肺功能参数的变化。结果治疗组总有效率为87.5%、对照组为67.5%,治疗组明显高于对照组,差异有显著性(P<0.05)。对照组治疗前后肺功能各项参数略有改善,但无显著性差异(P>0.05);治疗组治疗前后各项参数有明显改善(P<0.05),FEV1改变亦明显(P<0.05),而且治疗后肺功能与对照组治疗后FEV1比较呈显著性差异(P<0.05)。结论乌司他丁注射液能改善COPD急性加重期并发呼吸衰竭患者的肺功能,提高慢性阻塞性肺疾病急性加重期的治疗效果。
Objective To observe the effects and clinical effects of ulinastatin injection on pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods From January 2010 to June 2011, 80 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) diagnosed and treated in Respiratory Department of Shaoguan Railway Hospital were randomly divided into control group (40 cases) and treatment group (40 cases). The control group was given routine treatment. The treatment group was given ulinastatin injection on the basis of conventional treatment. After 10 days of treatment, the clinical curative effect and the changes of pulmonary function parameters of the two groups were observed. Results The total effective rate was 87.5% in the treatment group and 67.5% in the control group, which was significantly higher in the treatment group than in the control group (P <0.05). The parameters of pulmonary function before and after treatment in the control group improved slightly, but there was no significant difference (P> 0.05). The parameters of the treatment group before and after treatment were significantly improved (P <0.05) and FEV1 changed significantly (P <0.05) And after treatment, pulmonary function and FEV1 after treatment in the control group was significantly different (P <0.05). Conclusion Ulinastatin injection can improve pulmonary function in patients with acute exacerbation of COPD and improve the therapeutic effect of acute exacerbation of chronic obstructive pulmonary disease.