以６５℃热水灌喂ＮＩＨ小鼠１３周后，７８．５％的小鼠前胃粘膜鳞状上皮发生乳头状增生，固有膜血管充血和炎性细胞浸润等炎性粘膜改变。灌喂热水加亚硝基肌氨酸乙酯组，８５．７１％的小鼠前胃上皮发生癌变，明显高于对照组癌变率５３．５７％（Ｐ＜０．０１）。结果表明，热损伤可引起小鼠前胃粘膜炎症性改变，而炎症造成的粘膜损伤又增加了粘膜上皮对致癌物的敏感性。慢性热损伤可能是促癌因素之一。 After feeding NIH mice with hot water at 65°C for 13 weeks, squamous hyperplasia, proliferative membrane vascular congestion, and inflammatory cell infiltration were observed in 78.5% of the mouse squamous epithelium. In the group fed with hot water and nitrosyl sarcosine ethyl ester, 85.71% of mice had cancerous lesions in the epigastric epithelium, which was significantly higher than that in the control group (53.57%) (P<0.01). The results showed that thermal injury can cause inflammatory changes in the gastric mucosa of mice, and mucosal damage caused by inflammation increases the sensitivity of mucosal epithelium to carcinogens. Chronic heat injury may be one of the factors promoting cancer.