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目的探讨接受HAART治疗的HIV/AIDS患者肝损害的相关危险因素。方法收集接受HAART治疗的71例HIV/AIDS患者病例资料,比较两组患者的年龄、性别、感染途径、饮酒状况、CD4+T细胞数、HAART治疗方案、肝毒性药物的使用、HBV和/或HCV协同感染等对肝功能的影响。结果71例患者中HBV感染者9例,HCV感染者35例,其中HBV、HCV共同感染者5例;51例患者出现了肝功能异常。肝功能异常组与肝功能正常组HBV和/或HCV协同感染比率分别为63%和35%,差异有统计学意义(P=0.035),年龄、性别、感染途径、饮酒状况、CD4+T淋巴细胞数(<50)、HAART治疗方案、使用肝毒性药物的比率差异无统计学意义(P>0.05)。Logist回归分析HBV和/或HCV的协同感染是HAART患者肝功能损伤的危险因素。结论HBV和/或HCV与HIV的协同感染十分普遍,是HAART治疗HIV/AIDS患者肝功能损伤的重要危险因素。
Objective To investigate the risk factors of liver damage in HIV / AIDS patients receiving HAART. Methods A total of 71 HIV / AIDS patients receiving HAART were enrolled in this study. The age, sex, route of infection, drinking status, CD4 + T cell count, HAART regimen, hepatotoxicity, HBV and / HCV synergistic infection on liver function. Results Among the 71 patients, 9 were infected with HBV, 35 were infected with HCV, and 5 were co-infected with HBV and HCV. Fifty-one patients had liver dysfunction. The rates of co-infection of HBV and / or HCV in patients with abnormal liver function and those with normal liver function were 63% and 35%, respectively, with statistical significance (P = 0.035), age, sex, infection route, drinking status, CD4 + T lymphocyte There was no significant difference in the number of cells (<50), the HAART regimen, and the use of hepatotoxic drugs (P> 0.05). Logistic regression analysis of co-infection with HBV and / or HCV is a risk factor for liver damage in patients with HAART. Conclusions The co-infection of HBV and / or HCV with HIV is very common and is an important risk factor of HAART in the treatment of liver dysfunction in HIV / AIDS patients.