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目的分析首发脑梗死患者卒中后抑郁临床特征及其和病灶的相关性。方法选取2014年12月至2016年12月期间在我院就诊的首发脑梗死卒中患者68例,根据是否伴有抑郁分为:伴抑郁21例,为观察组,不伴抑郁47例,为对照组,观察两组患者临床特征,并分析脑梗死卒中后抑郁和病灶部位、病灶大小相关性。结果两组患者左侧大脑半球的比较发现:皮质下及额叶梗死率存在显著性差异(P<0.05),而右侧大脑半球梗死发生率未见统计学差异(P>0.05);观察组梗死灶直径≥3.6cm患者所占比例明显高于对照组,差异有统计学意义(P<0.05);观察组中病灶直径≥3.6cm的患者重度抑郁发生率明显高于直径<3.6cm的患者(P<0.05)。结论首发脑梗死卒中后抑郁患者的梗死灶常见于左侧大脑半球,且卒中后抑郁病情的严重程度和梗死灶直径的大小相关。
Objective To analyze the clinical features of post-stroke depression in patients with primary cerebral infarction and its correlation with the lesion. Methods Sixty-eight patients with stroke in our hospital from December 2014 to December 2016 were divided into two groups according to their depression: 21 with depression, and 47 cases with depression as observation group without depression Group. The clinical characteristics of the two groups were observed, and the correlation between depression and lesion location and lesion size was analyzed after stroke. Results Comparisons of the left hemisphere of the two groups showed that there was a significant difference (P <0.05) between the infarction rate of the cortex and the frontal lobe, but there was no significant difference in the incidence of infarction between the right hemisphere and the right hemisphere (P> 0.05) The proportion of patients with infarction diameter ≥3.6cm was significantly higher than that of control group (P <0.05). The incidence of major depression in patients with diameter ≥3.6cm in observation group was significantly higher than that in patients with diameter <3.6cm (P <0.05). Conclusions Infarction in the patients with first stroke after stroke is common in the left hemisphere, and the severity of post-stroke depression is related to the diameter of the infarct.