环孢菌素A(CsA)为11种氨基酸的多肽,临床上已用于防治器官移植排斥反应,以及自身免疫性疾病的治疗。CsA可抑制IL-2的产生,抑制辅协T细胞和细胞毒T细胞的作用。来文作者研究了CsA对体外胸腺上皮细胞(TEC)的增殖、胸腺素的产生和Ⅰ区抗原的表达,同时还对体外人TEC原代培养进行了研究。作者每日给C57BL/6幼鼠或成鼠体内注射CsA, Cyclosporine A (CsA) is a polypeptide of 11 amino acids that has been used clinically to prevent organ transplant rejection and the treatment of autoimmune diseases. CsA can inhibit the production of IL-2 and inhibit the role of co-recruiting T cells and cytotoxic T cells. The authors studied the proliferation of thymus epithelial cells (TEC) in vitro, the production of thymosin and the expression of antigen in region I, as well as the primary cultured human TEC in vitro. The authors daily C57BL / 6 pups or mice injected with CsA,