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目的:比较种植尿道黏膜上皮细胞的网状生物可降解尿道支架与单纯螺旋形尿道支架重建战伤后尿道狭窄的组织相容性及形态学变化。方法:成年新西兰雄兔18只,取原代培养兔尿道上皮细胞,种植于网状生物可降解尿道支架上,进行形态学鉴定及染色,观察存活状态。将种植尿道黏膜细胞的支架与单纯尿道支架,植入战伤性尿道狭窄动物模型,观察两种尿道支架重建损伤后尿道的组织相容性及形态学改变。结果:培养的尿道黏膜上皮细胞在网丝孔隙中黏附、增殖状态良好。结论:种植尿道黏膜上皮细胞的网状生物可降解尿道内支架,具有良好的修复重建战创伤后尿道狭窄的功能,有望成为修复重建战伤性尿道狭窄的有效方法。
OBJECTIVE: To compare the histocompatibility and morphological changes of urethral strictures after reconstructing war-wounded trauma with reticulated biodegradable urethral stents and simple spiral urethral stents. Methods: Eighteen adult New Zealand male rabbits were harvested from rabbit primary urethra and implanted into reticulated biodegradable urethral stent. Morphological identification and staining were performed to observe the survival status. The urethral mucosal cells and urethral stent were implanted into animal model of urethral stricture to observe the histocompatibility and morphological changes of urethra after the reconstruction of the two urethral stent. Results: The cultured urethral epithelial cells adhered in the pores of mesh, and proliferated well. CONCLUSION: Mesh-shaped biodegradable urethral stent placed in urethral mucosa epithelial cells has a good function of repairing post-traumatic urethral stricture. It is expected to be an effective method to repair and repair post-traumatic urethral stricture.