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本文报导了22个6-(取代丙烯酰氨)青霉烷酸化合物的合成.这类化合物系以相应的取代丙烯酸,通过混合酸酐或酰氯,在微碱性、低温下,与6APA进行缩合;再以N-乙基六氢吡啶或N,N′-二苄基乙二胺成盐纯化精制.它们的抗菌作用正在筛选中.
This paper reports the synthesis of 22 6- (substituted acrylamide) penicillanic acid compounds, which are condensed with 6APA by the substitution of acrylic acid and mixed anhydride or acid chloride at slightly alkaline and low temperature. Then purified by salt formation with N-ethylpiperidine or N, N’-dibenzylethylenediamine and their antibacterial activity is being screened.