心肌在缺血、缺氧状态下常出现房室传导阻滞,但发生的机制尚未阐明。本世纪20年代,国外学者发现腺苷具有负性变力、变时及变导效应,即降低心肌收缩力、减慢心率及引起房室传导的延缓或阻滞。此后,他们运用多种实验手段对腺苷的作用及电生理效应进行了探讨,并且获得了大量实验数据。腺苷做为阵发性室上性心动过速的有力拮抗剂在欧洲得到使用,为治疗心肌缺血、缺氧状态下发生的房室传导阻滞提供了一条新的治疗途径。 Myocardium in ischemia, hypoxia often appear atrioventricular block, but the mechanism has not yet been clarified. In the 1920s, foreign scholars found that adenosine has a negative variable force, variable time and variable effect, which reduces myocardial contractility, slow down the heart rate and lead to atrioventricular conduction delay or block. Since then, they used a variety of experimental methods on the role of adenosine and electrophysiological effects were discussed, and obtained a large number of experimental data. Adenosine, a potent antagonist of paroxysmal supraventricular tachyarrhythmias, has been used in Europe to provide a new therapeutic approach for treatment of myocardial ischemia and hypoxia-atrioventricular block.