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免疫球蛋白样转录物(immunoglobulin-like transcript,ILT)家族表达于髓系和淋系细胞表面,功能上可分为抑制性或激活性受体两大类,通过与相应的配体结合诱导免疫抑制或免疫应答作用。ILT2/4受体通过与其配体人类白细胞抗原-G(human leukocyte antigen-G,HLA-G)相互作用,传递抑制信号,调节免疫活性细胞的生物学功能或诱导耐受型DC细胞(tolerogenic dendritic cells,tDC)/调节性T细胞(regulatory T cells,Treg)/髓系衍生抑制性细胞(myeloid-derived suppressor cells,MDSCs)的产生。就ILTs受体在HLA-G免疫耐受机制中的研究进展作一综述。
The immunoglobulin-like transcript (ILT) family is expressed on the surface of myeloid and lymphoid cells and is functionally divided into two major classes of inhibitory or activating receptors that induce immunity by binding to the corresponding ligand Inhibit or immune response. ILT2 / 4 receptors transmit inhibitory signals, modulate the biological function of immunocompetent cells or induce tolerogenic dendritic (DC) cells by interacting with its ligand human leukocyte antigen-G (HLA-G) cells, tDC) / regulatory T cells (Treg) / myeloid-derived suppressor cells (MDSCs). The research progress of ILTs receptors in the mechanism of HLA-G immune tolerance is reviewed.