目的评估透明帽辅助法对降低结直肠息肉漏诊率的可行性及安全性。方法 100例接受同次两遍“串联式”肠镜检查的健康体检者,随机分为试验组和对照组,各50例。试验组第一遍采用透明帽辅助结肠镜检查+第二遍常规结肠镜检查;对照组两遍均采用常规结肠镜检查。比较两组操作时间、息肉检出率、息肉漏诊率及不良事件发生率。结果试验组第一遍肠镜检查的进镜时间为(263.22±92.06)s,短于对照组的(304.84±109.87)s,差异有统计学意义(P<0.05)。试验组息肉患者漏诊率为12.00%(6/50),低于对照组的34.00%(17/50),差异有统计学意义(P<0.05)。试验组患者息肉漏诊率为12.16%(9/74),低于对照组的29.17%(21/72),差异有统计学意义(P<0.05)。结论透明帽辅助技术是一种降低肠镜检查息肉漏诊、缩短进镜时间且安全、廉价的方法 ,值得临床推广使用。 Objective To evaluate the feasibility and safety of the transparent cap-assisted method in reducing the rate of misdiagnosis of colorectal polyps. Methods A total of 100 healthy subjects who underwent “double in-line” and “in-line” colonoscopy were randomly divided into test group and control group, 50 cases each. The first time the experimental group with transparent cap-assisted colonoscopy + the second regular colonoscopy; control group twice by conventional colonoscopy. The operation time, the detection rate of polyps, the rate of polyps misdiagnosis and the incidence of adverse events were compared between the two groups. Results The time of enteroscopy in the first pass of colonoscopy in the experimental group was (263.22 ± 92.06) s, which was shorter than that in the control group (304.84 ± 109.87) s, the difference was statistically significant (P <0.05). The rate of misdiagnosis in the experimental group was 12.00% (6/50), which was lower than that in the control group (34.00%, 17/50) (P <0.05). The rate of misdiagnosis of polyp in trial group was 12.16% (9/74), which was lower than that in control group (29.17%, 21/72) (P <0.05). Conclusion Transparent cap-assisted technique is a safe and inexpensive method to reduce the missed diagnosis of colon polyps, shorten the time to enter the mirror and is worthy of clinical promotion.