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目的:观察养血当归胶囊联合米非司酮治疗围绝经期功能性子宫出血患者的有效性和安全性。方法:将72例围绝经期功能性子宫出血患者随机分为对照组和观察组,各36例。对照组患者服用米非司酮,观察组患者使用养血当归胶囊联合米非司酮治疗,对比两组治疗3个月后的临床疗效、血清激素水平、子宫内膜变化和对肝肾功能影响。结果:治疗组患者治疗总有效率为86.1%,对照组患者总有效率61.1%,有明显差异(P<0.05);两组患者血清激素水平FSH、E_2、LH水平较治疗前均显著降低,治疗组血清激素水平下降优于对照组,有明显差异(P<0.05)。两组患者子宫内膜均明显变薄,治疗组患者治疗后子宫内膜变化较对照组显著,有明显差异(P<0.05)。两组患者治疗前后肝肾功能均无明显变化,无明显差异(P>0.05)。结论:养血当归胶囊能够提高米非司酮治疗围绝经期功能性子宫出血患者的临床疗效,且未增加明显的无不良反应,值得临床研究推广。
Objective: To observe the effectiveness and safety of Yangxue Danggui capsule combined with mifepristone in the treatment of patients with functional uterine bleeding during perimenopause. Methods: Seventy-two patients with functional uterine bleeding in perimenopausal period were randomly divided into control group and observation group, with 36 cases in each group. Control group patients taking mifepristone, observation group patients with nourishing angelica capsules combined with mifepristone treatment compared two groups after 3 months of treatment clinical efficacy, serum hormone levels, endometrial changes and liver and kidney function . Results: The total effective rate of treatment group was 86.1%, while the total effective rate of control group was 61.1% (P <0.05). Serum hormone levels of FSH, E_2 and LH in both groups were significantly lower than those before treatment, Serum hormone levels decreased better than the control group, there was a significant difference (P <0.05). The endometrium in both groups were significantly thinner, and the endometrial changes in the treatment group were significantly different from those in the control group (P <0.05). There was no significant difference between the two groups before and after treatment of liver and kidney function, no significant difference (P> 0.05). Conclusion: Yangxue Danggui capsule can improve the clinical curative effect of mifepristone in patients with functional uterine bleeding during perimenopausal period without any significant adverse reactions, which deserves to be popularized clinically.