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目的观察表皮生长因子受体2(HER-2)及凋亡抑制蛋白Survivin在胃癌组织中的表达,探讨其与临床病理的相关性及其临床意义。方法使用免疫组织化学法检测2002-2011年江苏盛泽医院79例未经放、化疗的胃癌患者组织中HER-2及Survivin蛋白的表达。并分析两者与胃癌患者临床病理学参数之间的关系。结果 79例胃癌患者,男女比例为2.59:1,中位年龄为67岁,HER-2蛋白在胃癌中的阳性表达与肿瘤分化程度、Lauren分型、淋巴结转移及临床分期相关(p<0.05),与性别、年龄、肿瘤直径、浸润深度不相关。Survivin与肿瘤分化程度相关(p<0.05),与性别、年龄、肿瘤直径、Lauren分型、浸润深度、淋巴结转移及临床分期不相关。HER-2在Survivin阳性的表达率(70.59%)明显高于在Survivin阴性表达组(9.09%()P<0.05)结论胃癌HER-2蛋白的阳性表达与肿瘤分化程度、Lauren分型、淋巴结转移及临床分期相关,可用于指导临床用药;Survivin表达可作为判断胃癌恶性程度和预后的重要指标,其与HER-2表达正相关,可促进胃癌细胞增殖。
Objective To observe the expression of epidermal growth factor receptor 2 (HER-2) and apoptosis-inhibitory protein Survivin in gastric carcinoma, and to explore its correlation with clinical pathology and its clinical significance. Methods The expression of HER-2 and Survivin protein in 79 patients with gastric cancer without radiotherapy and chemotherapy in Jiangsu Shengze Hospital from 2002 to 2011 were detected by immunohistochemistry. And analyze the relationship between the two and clinicopathological parameters of gastric cancer patients. Results The positive expression rate of HER-2 protein in gastric cancer was 79% (2.59: 1) and the median age was 67 years. The positive rate of HER-2 protein in gastric cancer was correlated with the degree of tumor differentiation, Lauren classification, lymph node metastasis and clinical stage , And gender, age, tumor diameter, depth of invasion is not relevant. Survivin was correlated with the degree of tumor differentiation (p <0.05), but not with gender, age, tumor diameter, Lauren classification, depth of invasion, lymph node metastasis and clinical stage. The positive expression rate of HER-2 in Survivin (70.59%) was significantly higher than that in Survivin negative (9.09% (P <0.05)) Conclusion The positive expression of HER-2 protein in gastric cancer correlated with tumor differentiation, Lauren’s classification, lymph node metastasis And clinical stage can be used to guide the clinical medication; Survivin expression can be used as an important indicator to determine the degree of malignancy and prognosis of gastric cancer, which is positively correlated with HER-2 expression, can promote gastric cancer cell proliferation.