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Objective To investigate the roles of maspin and kail expression in tumorigenesis and progression of gastric cancer.Methods Maspin and kail expressions were detected in normal gastric mucosa (n = 182), gastric dysplasia (n = 69), and gastric cancer (n = 113) by immunohisto-chemistry. Their expressions were compared with clinicopathological parameters of tumors. Relationship between maspin and kai1 expression was also concerned in gastric cancer.Results The positive rates ofmaspin expression were 79.8% (145/182), 75.4% (52/69), and 50.4% (57/113) in normal gastric mucosa, gastric dysplasia, and gastric cancer, while those of kail expression were 81.9% (149/182), 65.2% (49/69),and 58.4% (66/113) in corresponding tissues respectively. Gastric cancer less frequently expressed maspin than the normal gastric mucosa and gastric dysplasia (P ＜ 0.05), while dysplasia and cancer showed less frequent expression of kail than normal mucosa (P ＜ 0.05). Maspin expression showed negative association with invasive depth, metastasis, Laurens and histological classifications (P ＜ 0.05), but not with tumor size, Borrmanns classification, growth pattern or TNM staging (P ＞ 0.05). Kail expression was negatively correlated with invasive depth, metastasis, growth pattern, Laurens and histological classifications (P ＜ 0.05), but not with tumor size, Borrmanns classification or TNM staging (P ＞ 0.05). Maspin and kail were collaboratively expressed in gastric cancer (P ＜ 0.05).Conclusions Down-regulated expressions of maspin and kail play an important role in gastric carcinogenesis. Abnormal expression of maspin and kail might have inhibitory effects on invasion and metastasis of gastric cancer and act as an effective and objective marker to indicate the pathobiological behaviors of gastric cancer.