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目的:探讨抗生素相关性腹泻(AAD)患儿的发生情况和相关因素。方法:统计2007年12月～2010年12月我院儿科2 502例使用抗生素的住院患儿AAD的发病率,并对导致发生AAD的主要因素进行调查、分析。结果:AAD的发病率为3.67%。AAD组病例年龄3岁以下、抗生素应用7 d以上、两种以上抗生素联用的比例明显高于未发生AAD组,两组比较差异均有统计学意义(P<0.05)。结论:儿童抗生素相关性腹泻的发病率高,与多种因素有关,规范抗生素的应用,严格控制广谱抗生素的使用,是预防控制抗生素相关性腹泻的关键措施。
Objective: To investigate the incidence and related factors of antibiotic-associated diarrhea (AAD) in children. Methods: From December 2007 to December 2010, the incidence of AAD in infants hospitalized with antibiotics in 2 502 pediatric patients in our hospital was calculated. The main factors leading to AAD were investigated and analyzed. Results: The incidence of AAD was 3.67%. The age of AAD patients was less than 3 years old and antibiotics were used for more than 7 days. The proportion of two or more antibiotics in AAD group was significantly higher than that of AAD group. There was significant difference between the two groups (P <0.05). Conclusions: The incidence of antibiotic-associated diarrhea in children is high and related to many factors. Regulating the application of antibiotics and strictly controlling the use of broad-spectrum antibiotics are the key measures to prevent and control antibiotic-associated diarrhea.