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通过小鼠实验提出了一种亮白光LED联合古典音乐疗法.遭受过慢性不可预知性应激的小鼠被随机分成3组,均饲养在350 lx、光周期为12小时明亮12小时黑暗的环境中.对照组(C):不做任何处理.五行音乐组(M):每天播放2个小时古典音乐.五行音乐+光照组(M+B):每天播放2小时古典音乐并采用5000 lx的白光LED照射.30天后用糖水偏爱度测试和强迫游泳实验来评估抑郁程度.与C组相比,M和M+B组的小鼠表现出更短的游泳不动时间和更长的游泳和攀爬时间 (p<0.001).M+B组小鼠的游泳不动时间(52.3±25.18 s)要短于M组(78.9±14.82 s),且差异存在统计学意义(t(9)=3.414,p=0.008<0.05).亮白光LED联合古典音乐疗法能够提高应激小鼠的活力,具有一定的抗抑郁作用.“,”The treatment of bright white LED combined with classical music was proposed by laboratory mice. Mice suffered from chronic mild stress were divided randomly into three groups and exposed to 12:12 h bright light:dark (350 lx) conditions. The control group (C) received no treatment. The classical music group (M) was treated with classical music of 2 h per day. The classical music + bright light group (M+B) was treated daily with classical music of 2 h and 5 000 lx white LED light. Thirty days later, depression-like behaviors were assessed using saccharin solution preferences and forced swim tests. Mice in M and M+B demonstrated signi cantly shorter immobility times and longer climbing times and swimming times compared to those in C (p<0.001). It was observed that M+B experienced shorter immobility times (52.3±25.18 s) than M (78.9±14.82 s), and there was significant difference between two groups(t(9)=3.414, p=0.008<0.05). The combination therapy of bright white LED and classical music raised the vitality of mice and possessed antidepressant effect.