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目的:通过观察心绞痛患者血清C-反应蛋白(CRP)、血浆凝血因子(FIB)水平的变化,评价CRP和FIB联合检测对心绞痛患者心血管病事件发生的预测价值。方法:选择冠心病(CHD)患者65例,分为2组,其中稳定型心绞痛组(SAP)30例、不稳定型心绞痛组(UAP)35例,另选30例健康者作为对照组。检测各组血液中CRP、FIB水平。出院后随访3个月,记录心血管事件的发生情况。结果:心绞痛组的CRP和FIB水平明显高于对照组;UAP组的CRP和FIB水平显著高于SAP组(P<0.01);联合检测发现,CRP及FIB水平均升高的患者,心血管事件的发生率明显高于CRP及FIB均正常者(P<0.05)。结论:CRP和FIB水平的高低与心绞痛的严重程度有关,CRP和FIB联合检测对心绞痛患者心血管事件的发生有预测价值。
Objective: To evaluate the predictive value of combined use of CRP and FIB in the assessment of cardiovascular events in patients with angina pectoris by observing the changes of serum C-reactive protein (CRP) and plasma clotting factor (FIB) levels in patients with angina pectoris. Methods: Sixty-five patients with coronary heart disease (CHD) were enrolled in this study. They were divided into two groups, including 30 patients with stable angina (SAP), 35 patients with unstable angina (UAP) and 30 healthy controls. The blood levels of CRP and FIB in each group were detected. Followed up for 3 months after discharge, recorded the occurrence of cardiovascular events. Results: The levels of CRP and FIB in angina pectoris group were significantly higher than those in control group. The levels of CRP and FIB in UAP group were significantly higher than those in SAP group (P <0.01). The combination of CRP and FIB levels in patients with angina pectoris was significantly higher than those in control group The incidence was significantly higher than those with normal CRP and FIB (P <0.05). Conclusion: The levels of CRP and FIB are related to the severity of angina pectoris. Combined detection of CRP and FIB has predictive value for the occurrence of cardiovascular events in patients with angina pectoris.