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目的:研究左乙拉西坦治疗儿童癫癎疗效达完全控制及其影响因素,为临床合理使用左乙拉西坦,使其效果最大化提供依据。方法:采用前瞻性研究,按纳入及排除标准纳入病例;疗程≥3个月,统计完全控制率;对完全控制组和非完全控制组患者进行不同发作类型、治疗方案、年龄及病因等对照研究。结果:共纳入癫癎患儿110例,其中完全控制56例(50.9%)。不同发作类型、病因及不同治疗方案的完全控制率比较差异有统计学意义(P<0.05)。结论:左乙拉西坦治疗儿童癫癎有较高的完全控制率,完全控制率与发作类型、治疗方案及病因有关。
Objective: To study the efficacy and safety of levetiracetam in the treatment of children with epilepsy, and to provide evidence for the rational use of levetiracetam in clinical practice. Methods: A prospective study was conducted to enrolle patients according to inclusion and exclusion criteria. Patients in treatment ≥3 months were enrolled in the study. Complete control rates were calculated. Patients in complete control group and non-complete control group were compared with different types of seizures, treatment options, age and etiology . Results: A total of 110 epileptic children were enrolled, of which 56 cases (50.9%) were completely controlled. The complete control rate of different seizure types, etiologies and different treatment regimens was statistically significant (P <0.05). Conclusion: Levetiracetam has a higher complete control rate in children with epilepsy. The complete control rate is related to the type of attack, treatment regimen and etiology.