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目的了解儿童接种麻疹风疹联合减毒活疫苗(简称麻风疫苗)的免疫效果。方法采用分层系统抽样方法抽取宁波市2009年7月1日—9月30日出生的本地儿童,在接种麻风疫苗接种后3个月采集血标本,采用酶联免疫吸附试验检测麻疹IgG和风疹IgG抗体。结果 1053名儿童采血检测,其中男童591人,女童462人;城市520人,农村533人。儿童麻疹、风疹IgG抗体阳性率分别为97.34%和95.25%。麻疹、风疹IgG抗体浓度最小值均为0 mIU/ml,最大值分别为682801.01和23475.72 mIU/ml,平均浓度分别为4233.32和161.74 mIU/ml;农村麻疹IgG抗体平均浓度为5611.55 mIU/ml,高于城市的3171.17 mIU/ml,性别间差异均无统计学意义(P>0.05)。结论儿童接种麻风疫苗后,能获得较理想的免疫应答。
Objective To understand the immunization effect of measles and rubella combined attenuated live vaccine (referred to as leprosy vaccine) in children. Methods The local children born in Ningbo City from July 1 to September 30, 2009 were collected by stratified systematic sampling method. The blood samples were collected 3 months after the inoculation of leprosy, and the levels of measles IgG and rubella IgG were detected by enzyme-linked immunosorbent assay antibody. Results A total of 1053 children were tested for blood sampling, including 591 boys and 462 girls; 520 in urban areas and 533 in rural areas. The positive rates of measles and rubella IgG in children were 97.34% and 95.25% respectively. Measles and rubella IgG antibody concentrations were minimum 0 mIU / ml, the maximum were 682801.01 and 23475.72 mIU / ml, the average concentrations were 4233.32 and 161.74 mIU / ml; the average concentration of measles IgG in rural areas was 5611.55 mIU / ml, high In the city of 3171.17 mIU / ml, gender differences were not statistically significant (P> 0.05). Conclusion Children receiving leprosy vaccine can obtain better immune response.