人疟原虫严格的宿主专一性极大地阻碍了疟疾的实验研究。除猩猩之外,两属南美洲的猴,夜猴和松鼠猴可作为“适应”株的感受者,但往往需首先在切脾动物经过一系列的过渡。因这些动物数量有限,价格昂贵,显然降低了其作为模型的使用意义。在试图克服这些障碍的努力中,作者成功地利用了B和T细胞缺陷小鼠(如严重综合免疫缺陷的SCID或先天无胸腺的NIHⅢ小鼠)。 The rigorous host specificity of human Plasmodium has greatly hampered the experimental study of malaria. In addition to the orangutan, two South American monkeys, the night monkey and the squirrel monkey, can be used as the “adaptive” strains of the recipient, but often first need to undergo a series of transitions in the spleen-splitting animals. Because of the limited number of these animals, they are expensive and obviously reduce their usefulness as models. In an effort to overcome these obstacles, the authors have successfully utilized B and T cell deficient mice (eg, SCID or congenital athymic NIH III mice with severe combined immunodeficiency).