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目的分析元宫Cu365型与花式HCu280型宫内节育器(IUD)的效果及不良反应。方法将2013年3月-2015年2月来医院欲放置IUD的220例已婚育龄女性分为对照组(置入花式HCu280型IUD)与观察组(置入元宫Cu365型IUD),每组110例。比较随访期间两组患者IUD有效性、可接受性及不良反应发生率。结果随访过程中,共4例患者未完成随访,对照组与观察组各2例。两组随访1、3、6、12个月时累计带器妊娠、累计IUD脱落及累计IUD嵌顿发生率比较差异均无统计学意义(P>0.05);随访1、3、6个月时累计因症取出率及累计终止率比较差异均无统计学意义(P>0.05);随访12个月时累计因症取出率及累计终止率比较差异有统计学意义(P<0.05)。两组随访12个月时,观察组累计续用率(93.51%)高于对照组(83.33%),差异有统计学意义(P<0.05)。两组随访1、3个月时,子宫出血、经期延长、经量增多、白带增多发生率比较差异有统计学意义(P<0.05);随访6、12个月时,以上各指标比较差异均无统计学意义(P>0.05)。两组随访1、3、6、12个月时,疼痛发生率比较差异均无统计学意义(P>0.05)。随着随访时间的延长,有子宫内膜压迹的患者逐渐减少,但有子宫内膜瘀斑和溃疡的患者逐渐增多。随访1、3个月时,两组子宫内膜压迹发生率比较差异有统计学意义(P<0.05);随访6、12个月时,两组子宫内膜瘀斑及溃疡发生率比较差异有统计学意义(P<0.05)。两组VAS评分比较差异有统计学意义(P<0.05)。两组随访1、3个月时VAS评分比较差异有统计学意义(P<0.05);随访6、12个月时VAS评分比较差异无统计学意义(P>0.05)。结论元宫Cu365具有避孕效果稳定,可接受性高,降低子宫出血及疼痛等不良反应发生率等优点,值得临床推广应用。
Objective To analyze the efficacy and adverse reactions of Cu365 type and HCu280 type IUD. Methods A total of 220 married women of childbearing age who wanted to place the IUD from March 2013 to February 2015 were divided into control group (HCU280 IUD) and observation group (Cu365 IUD) Group of 110 cases. The IUD effectiveness, acceptability and incidence of adverse reactions in both groups during follow-up were compared. Results During the follow-up, a total of 4 patients were not followed up, 2 cases in the control group and observation group. There was no significant difference in cumulative IUD shedding and cumulative IUD incarceration between the two groups at 1, 3, 6 and 12 months of follow-up (P> 0.05); at 1, 3 and 6 months of follow-up There was no significant difference in cumulative removal rate and cumulative termination rate (P> 0.05). The cumulative removal rate and cumulative termination rate at 12 months of follow-up were statistically significant (P <0.05). When the two groups were followed up for 12 months, the cumulative continuous rate (93.51%) in the observation group was higher than that in the control group (83.33%), with significant difference (P <0.05). The incidences of uterine bleeding, menstrual prolongation, menstrual flow increase and leucorrhea increase were significantly different between the two groups at 1 month and 3 months (P <0.05). At 6 and 12 months of follow-up, the differences of the above indexes No statistical significance (P> 0.05). There were no significant differences in the incidence of pain between the two groups at 1, 3, 6 and 12 months of follow-up (P> 0.05). With the extension of follow-up, patients with endometrial indentation gradually decreased, but patients with endometrial ecchymosis and ulcers gradually increased. The follow-up 1,3 months, the incidence of endometrial indentation was significantly different between the two groups (P <0.05); at 6 and 12 months follow-up, the incidence of endometrial ecchymosis and ulcer in the two groups were significantly different There was statistical significance (P <0.05). There was significant difference between the two groups in VAS score (P <0.05). There was significant difference in VAS scores between the two groups at 1 and 3 months of follow-up (P <0.05). There was no significant difference in VAS score between the 6 and 12-month follow-up (P> 0.05). Conclusion Yuan Palace Cu365 with stable contraceptive effect, high acceptability, reduce the incidence of uterine bleeding and pain and other adverse reactions, etc., worthy of clinical application.