上海交大医学院研究员陈学进课题组和瑞金医院教授李小英课题组合作,首次发现父亲的心理应激通过表观遗传等机制可调控子代的糖代谢状况,进一步证实了环境因素介导的跨代遗传调控作用。相关研究成果近日发表于《细胞代谢》。大量人群流行病学研究表明,心理应激与多个疾病的发生发展密切相关。近来的研究表明,母亲的心理应激,尤其是妊娠期间的应激,可促进 Chen Xuejin, a researcher at Shanghai Jiaotong University School of Medicine, and Li Xiaoying, a professor at Ruijin Hospital, collaborated for the first time to find out that father’s psychological stress regulates the glycometabolism status of offspring by epigenetic mechanisms and further confirms that environmental factors mediated transgenerational heritability Regulation. Relevant research results recently published in “cell metabolism.” A large number of population epidemiological studies have shown that psychological stress and a number of diseases are closely related to the occurrence and development. Recent studies have shown that the mother’s psychological stress, especially during pregnancy, can promote