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顽固性心衰是血管扩张剂治疗的主要适应症。血管扩张剂的分类,特点和不良反应:按主要作用部位分为:①扩张静脉:硝酸甘油(NTG)、二硝基异山梨醇(消心痛、ISDN);②扩张小动脉:酚妥拉明,苯苄胺、肼苯哒嗪(HDZ)和钙阻滞剂;③均衡扩张动、静脉:硝普钠、哌唑嗪(PZN)、三甲氧唑嗪和血管紧张素转换酶抑制剂(ACEI)如巯甲丙脯酸,Enalapril,MK—521等。硝酸酯类降低前负荷(LVFP),缩小心室容积,减轻肺充血,但改善低心排量的作用不大。因其扩张冠状动脉、降低心肌
Refractory heart failure is the main indication for the treatment of vasodilators. Vasodilators classification, characteristics and adverse reactions: According to the main role of the site is divided into: ① expansion of the vein: nitroglycerin (NTG), dinitro isosorbide (resolving heart pain, ISDN); ② dilatation of the small artery: phentolamine , Benzene benzylamine, hydralazine (HDZ) and calcium blockers; ③ balanced expansion of venous: sodium nitroprusside, prazosin (PZN), trimazosin and angiotensin converting enzyme inhibitor ) Such as captopril, Enalapril, MK-521 and the like. Nitrates reduce preload (LVFP), reduce ventricular volume, reduce pulmonary congestion, but to improve the low cardiac output is not much effect. Because of its expansion of the coronary artery, reduce myocardial