目的观察葡萄糖-6-磷酸脱氢酶(G—6—PD)活性与鼻咽癌(NPC)的关系。方法分别对108例男性鼻咽癌患者与75例男性健康人进行G—6—PD活性检测。结果鼻咽癌患者平均G—6—PD活性为7.53v/gHb,明显低于健康人平均G—6—PD活性(8.92v/gHb)但G—6—PD活性水平在不同大小肿瘤及淋巴结转移患者间无明显差别。结论G—6—PD活性低下或缺乏的患者较G—6—PD活性正常的人易发生鼻咽癌。 Objective To observe the relationship between glucose-6-phosphate dehydrogenase (G-6-PD) activity and nasopharyngeal carcinoma (NPC). Methods G-6-PD activity was detected in 108 male patients with nasopharyngeal carcinoma and 75 healthy male subjects. Results The average G-6-PD activity of nasopharyngeal carcinoma patients was 7.53v / gHb, which was significantly lower than that of healthy individuals (8.92v / gHb) There was no significant difference between metastatic patients. Conclusions Patients with low or poor G-6-PD activity are more likely to develop NPC than those with normal G-6-PD activity.