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目的探讨胃粘膜萎缩与幽门螺杆菌（ＨＰ）感染在老年人反流性食管炎（ＲＥ）的作用。方法用内镜、组织学检查，血清胃蛋白酶原Ⅰ、Ⅱ（ＰＧⅠ、Ⅱ）测定、快速尿素酶及美蓝染色对４９例老年反流性食管炎患者进行胃粘膜萎缩及ＨＰ感染测定。结果老年ＲＥ患者重度胃粘膜萎缩百分率、ＨＰ感染率显著低于对照组（Ｐ值分别＜０．００５及０．０１）。ＲＥ组ＰＧⅠ、Ⅱ比率显著高于对照组（Ｐ＜０．００１）。结论提示老年ＲＥ患者ＨＰ感染少，胃粘膜萎缩轻、胃酸分泌相对正常，该结果为老年ＲＥ正确治疗提供了基础
Objective To investigate the role of gastric mucosal atrophy and Helicobacter pylori (HP) infection in reflux esophagitis (RE) in the elderly. Methods Gastric mucosal atrophy and HP infection were measured in 49 elderly patients with reflux esophagitis by endoscopy, histological examination, serum pepsinogen Ⅰ, Ⅱ (PG Ⅰ, Ⅱ), rapid urease and methylene blue staining. Results The percentage of severe gastric mucosal atrophy and HP infection in elderly patients with RE were significantly lower than those in the control group (P <0.005 and 0.01, respectively). The ratio of PGⅠ and Ⅱ in RE group was significantly higher than that in control group (P <0.001). Conclusions suggest that elderly patients with RE less HP infection, gastric mucosal atrophy, gastric acid secretion is relatively normal, the results provide the basis for the correct treatment of elderly RE