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目的:观察射干麻黄汤对哮喘豚鼠引喘潜伏期及抗炎作用。方法:观察射干麻黄汤对哮喘豚鼠引喘潜伏期的影响,并通过二甲苯所致小鼠耳廓肿胀实验及对小鼠腹腔毛细血管通透性的影响来评价其抗炎疗效。结果:射干麻黄汤高中剂量组能显著延长哮喘豚鼠的引喘潜伏期,明显抑制小鼠耳廓的肿胀程度及腹腔毛细血管的通透性(P<0.01),低剂量组亦有一定的作用。结论:射干麻黄汤具有明显的平喘抗炎作用。
Objective: To observe the Shegan Mahuang Decoction induced asthma in guinea pigs latency and anti-inflammatory effects. Methods: To observe the effect of She Gan Ma Huang Decoction on the latent period of asthma induced asthma in guinea pigs, and to evaluate the anti-inflammatory effect of xylene-induced mouse ear swelling test and its effect on peritoneal capillary permeability. Results: Shegan Mahuang decoction could significantly prolong the latent period of asthma induction in asthmatic guinea pigs, significantly inhibit the auricle swelling and peritoneal capillary permeability (P <0.01), and also play a role in low dose group. Conclusion: Shegan Mahuang decoction has obvious antiasthmatic and anti-inflammatory effects.