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采用霍恩氏法和蓄积系数法对二氧化氯ClO2 、亚氯酸盐ClO- 2 和氯酸盐ClO- 3水溶液以及ClO2混合水溶液对小鼠急性毒性和蓄积毒性进行了测试 ,并通过对大鼠 90天喂养试验 ,研究了ClO2 及其副产物ClO- 2 和ClO- 3混合水溶液的亚慢性毒性 ,包括对大鼠体重增长、食物利用率、血液学指标、血清生化指标、肝 (肾 ) /体重比值方差统计分析以及肝 (肾 )病理组织学显微检测。结果表明 ,2 76.5mg/l的ClO2 水溶液 ,2 0 0mg/l的NaClO2 和NaClO3水溶液以及总浓度为 553mg/lClO2 混合水溶液均为实际无毒水溶液 ;2 76.5mg/l的ClO2 、2 0 0mg/l的NaClO2 和NaClO3水溶液也是无明显蓄积性的水溶液 ;ClO2 混合液对大鼠体重增长和食物利用率没有产生显著性影响 (p >0 .0 5) ;对大鼠血液学指标 ,如白细胞计数 (WBC)、血红蛋白 (Hb)均未产生影响 (p >0 .0 5) ;对谷—丙转氨酶 (ALT)、总蛋白 (TP)、白蛋白 (ALB)和球蛋白 (GLO)的检测表明 ,其对照组和高剂量组雌雄相比无显著性差异 (p >0 .0 5) ;各试验组和对照组的大鼠肝体比 (% )和肾体比 (% )经方差分析 ,各组之间均无明显差别 (p >0 .0 5) ;病理组织学检查结果显示 ,各试验组和对照组其肝、肾组织均未见病变。
The Hoechst and accumulation coefficient method was used to test the acute toxicity and accumulative toxicity of chlorine dioxide ClO2, chlorite ClO-2 and chlorate ClO-3 aqueous solution and ClO2 mixed aqueous solution, The 90-day feeding experiment was carried out to study the sub-chronic toxicity of ClO2 and its by-products mixed aqueous solution of ClO-2 and ClO-3, including weight gain, food utilization, hematological indexes, serum biochemical indexes, / Body weight ratio statistical analysis of variance and liver (kidney) histopathology microscopic examination. The results showed that 2 76.5mg / l ClO2 aqueous solution, 200mg / l NaClO2 and NaClO3 aqueous solution and 553mg / l ClO2 mixed aqueous solution were all practical non-toxic aqueous solution; 2 76.5mg / l ClO2, 200mg / l NaClO2 and NaClO3 aqueous solution is also no significant accumulation of aqueous solution; ClO2 mixture on weight gain and food utilization did not have a significant effect (p> 0.05); hematological indicators such as white blood cell count (WBC) and hemoglobin (Hb) (p> 0.05). The detection of ALT, total protein (TP), albumin (ALB) and globulin (GLO) (P> 0.05). There was no significant difference between male and female in the control group and high-dose group (p> 0.05). The ratio of liver to body (%) and the ratio of kidney to body There was no significant difference between the groups (p> 0.05). The histopathological examination showed that there was no pathological change in the liver and kidney of each experimental group and control group.