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亚胺-154(ICRF-154)其化学名称为乙二胺四乙酰亚胺(Ethylene diamine tetraacetylimide),又名1,2-双(3,5-二氧哌嗪基)乙烷[1,2-bis(3,5-di-oxopiperazine-l-yl)ethane]。据报道,对多种实验肿瘤有明显抑制作用,临床初步观察对胃癌、肺癌、乳腺癌、网状细胞肉瘤有一定的缓解作用。南京军区总医院首先试用于银屑病的治疗,经33例临床观察,取得良好的治疗效果,显效率81.8％。其特点是毒性小,使用方便,长期口服对肝、肾功能及血象无甚影响,现正进一步扩大临床,肯定疗效,推广使用。
The chemical name of imine-154 (ICRF-154) is ethylene diamine tetraacetylimide, also known as 1,2-bis (3,5-dioxopiperazinyl) ethane -bis (3,5-di-oxopiperazine-l-yl) ethane]. It has been reported that a significant inhibitory effect on a variety of experimental tumors, preliminary clinical observations of gastric cancer, lung cancer, breast cancer, reticular cell sarcoma have some relief. Nanjing Military Region General Hospital first trial for the treatment of psoriasis, 33 cases of clinical observation, and achieved good therapeutic effect, markedly effective rate of 81.8%. It is characterized by small toxicity, easy to use, long-term oral no effect on the liver, kidney function and blood, and is now further expanding clinical, positive effect, promote the use.