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选用3H-TdR释放法及掺入法分别检测LAK细胞活性、LAK细胞增殖功能及9种临床常用肺癌化疗药物对LAK细胞抗肿瘤活性的影响。结果显示,不同化疗药物对IL-2诱导LAK细胞活性的影响不同,同种化疗药物不同浓度间的影响也有差异。卡铂(Carbo)、足叶乙甙(VP16)、5-氟尿嘧啶(5-Fu)有增强作用;环磷酰胺(CTX)、顺铂(CDDP)、长春新碱(VCR)、甲氨喋呤(MTX)对IL-2诱导LAK细胞活性无明显影响;阿霉素(ADM)、丝裂霉素(MMC)在较高浓度时,抑制LAK细胞活性产生。除CTX外的8种药物均显著抑制LAK细胞增殖功能。实验表明:常规剂量的化疗不会抑制LAK细胞活性的产生,5-Fu、Carbo、VP16与IL-2结合抗癌可望产生协同疗效.IL-2先于化疗给药并维持至化疗后一定时间,其联合抗癌效果可能更佳。
3H-TdR release method and incorporation method were used to detect the effects of LAK cell activity, LAK cell proliferation function and 9 clinical commonly used lung cancer chemotherapy drugs on the anti-tumor activity of LAK cells. The results showed that different chemotherapeutic agents had different effects on the activity of IL-2 induced LAK cells, and the effects of different concentrations of the same chemotherapeutic agents were also different. Enhanced effects of Carbo, VP16, and 5-Fu; cyclophosphamide (CTX), cisplatin (CDDP), vincristine (VCR), methotrexate (MTX) had no significant effect on IL-2 induced LAK cell activity; adriamycin (ADM) and mitomycin (MMC) inhibited LAK cell activity at higher concentrations. All 8 drugs except CTX significantly inhibited LAK cell proliferation. Experiments show that: conventional doses of chemotherapy will not inhibit the production of LAK cells, 5-Fu, Carbo, VP16 and IL-2 combined anti-cancer is expected to produce a synergistic effect. IL-2 is administered prior to chemotherapy and maintained for a certain period of time after chemotherapy, and its combined anti-cancer effect may be better.