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肺部因具有肺泡上皮层厚度薄、表面积大、毛细血管丰富、代谢反应相对较少等有利于药物吸收转运的特点,已成为一些易被酶降解的作用于全身的蛋白质类药物和治疗肺部疾病药物的重要给药靶器官。随着纳米科学的迅速发展,肺部给药新剂型正成为药物制剂研究的一个新热点。文中结合肺部的生理基础和肺部用药的情况,着重从剂型特点、模型药物、载体材料、制备方法等方面,对包括纳米粒、多孔纳米粒集合体粒子、微球、大多孔粒子和脂质体在内的几种肺部给药新剂型的最新研究动态进行综述。
Due to the pulmonary alveolar epithelial layer with thin, large surface area, capillary rich, relatively few metabolic reactions conducive to drug absorption and transport characteristics, has become susceptible to enzyme degradation of the body’s role in the protein drugs and the treatment of the lungs An important target organ of disease drug. With the rapid development of nanoscience, a new type of pulmonary drug delivery is becoming a new hot spot in the research of pharmaceutical preparations. Combined with the physiological basis of the lungs and the pulmonary medication, this paper focuses on the characteristics of the lungs, including the characteristics of the dosage form, the model drug, the carrier material, the preparation method and the like, including nanoparticles, porous nanoparticle aggregate particles, Plastids, several new formulations of pulmonary administration of the latest research developments are reviewed.