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BACKGROUND:Predicting the outcome of stroke during the acute phase is difficult.Accurate methods for predicting outcomes could assist clinicians and families to make correct decisions in resource-poor environments. OBJECTIVE:To determine thyroid hormone levels in patients with ischemic or hemorrhagic stroke at the early stage,and to investigate its correlation with stroke prognosis. DESIGN,TIME AND SETTING:A comparative,observational study was performed at the Department of Emergency,Tertiary-care University Affiliated Hospital from January 2004 to January 2006. PARTICIPANTS:A total of 113 patients presenting to the Emergency Department within 3 hours of stroke symptom onset were approached for enrollment in the study.The patients were diagnosed by computer tomography examination,and comprised 87 ischemic stroke and 26 hemorrhagic stroke patients. METHODS:Following a thorough history and examination by emergency physicians,venous blood samples were collected from each patient.Thyroid-stimulating hormone(TSH),free triiodothyronine (free T3),and free thyroxine(free T4) levels were measured using a chemiluminescence method. The nerve function of patients was evaluated with Glasgow Coma Scale(GCS) score,and the patients were accordingly assigned to two subgroups-mild stroke(GCS≥9) and severe stroke (GCS≤8). MAIN OUTCOME MEASURES:Blood levels of TSH,free T3 and free T4;mortality at 7 days. RESULTS:Mean TSH values in hemorrhagic stroke patients with GCS≤8 were significantly greater than those in ischemic stroke patients with GCS≤8 and GCS≥9(P<0.05).Compared with patients who survived,the highest TSH levels were detected in patients that had died within 7 days. Correlation analysis results revealed a significant negative relationship between GCS values and TSH levels in patients with hemorrhagic stroke(r=-0.552,P<0.01),and no correlation was determined between GCS values and TSH levels in patients with ischemic stroke(r=0.239,P>0.05). CONCLUSION:In patients with hemorrhagic stroke,high TSH levels were observed within the first 3 hours of stroke onset,which could be considered an indicator of poor prognosis.
BACKGROUND: Predicting the outcome of stroke during the acute phase is difficult. Accurate methods for predicting outcomes could assist clinicians and families to make correct decisions in resource-poor environments. OBJECTIVE: To determine thyroid hormone levels in patients with ischemic or hemorrhagic stroke at the early stage, and to investigate its correlation with stroke prognosis. DESIGN, TIME AND SETTING: A comparative, observational study was performed at the Department of Emergency, Tertiary-care University Affiliated Hospital from January 2004 to January 2006. PARTICIPANTS: A total of 113 patients presenting to the Emergency Department within 3 hours of stroke symptom onset were approached for enrollment in the study.Thepatient were diagnosed by computer tomography examination, and comprised 87 ischemic stroke and 26 hemorrhagic stroke patients. METHODS: Following a thorough history and examination by emergency physicians, venous blood samples were collected from each patient. hyroid-s The nerve function of patients was evaluated with a Glasgow Coma Scale (GCS) score, and the patients were able assigned to a chemiluminescence method MAIN OUTCOME MEASURES: Blood levels of TSH, free T3 and free T4; mortality at 7 days. RESULTS: Mean TSH values in hemorrhagic stroke patients with GCS ≤ 8 were significantly greater than those in ischemic stroke patients with GCS ≤ 8 and GCS ≥ 9 (P <0.05). Compared with patients who survived, the highest TSH levels were detected in patients that had died within 7 days. Correlation analysis results revealed a significant negative relationship between GCS values and TSH levels in patients with hemorrhagic stroke (r = -0.552, P <0.01), and no correlation was determined between GCS values and TSH levels in patients with ischemic stroke (r = 0.239, P> 0.05). CONCLUSION: In patients with hemorrhagic stroke, high TSH levels were observed within the first 3 hours of stroke onset, which could be considered an indicator of poor prognosis.