论文部分内容阅读
目的 了解急性白血病患儿完全缓解 (CR)后骨髓幼稚细胞比例出现 0 0 5～ 0 2 5时对预后的影响 ,为临床治疗策略的调整提供依据。方法 对 1998～ 2 0 0 1年上海儿童医学中心收治急性白血病患儿CR后按骨髓幼稚细胞比例分为A组 (<0 0 5 )和B组 (0 0 5～ 0 2 5 ) ;B组又分为B1(0 0 5～ 0 10 )、B2 (～ 0 15 )、B3(～ 0 2 5 ) 3个亚组 ,分析各组与急性白血病复发的关系。结果 急性淋巴细胞白血病 (ALL)患儿CR后骨髓幼稚细胞≥ 0 10时 ,复发率与阴性对照组差异有显著性 ;急性非淋巴细胞白血病 (ANLL)患儿CR后骨髓幼稚细胞≥ 0 15时 ,复发率与阴性对照组差异有显著性。结论 ALL患儿CR后骨髓中原始淋巴细胞 +幼淋巴细胞≥ 0 10及ANLL患儿CR后骨髓中原始粒细胞 +早幼粒细胞或原始单核细胞 +幼单核细胞≥ 0 15时应考虑及时调整治疗方案。
Objective To investigate the prognosis of children with acute leukemia after complete remission (CR), and to provide a basis for the adjustment of clinical treatment strategies. Methods The percentages of bone marrow blast cells in children with acute leukemia from 1998 to 2001 in Shanghai Children’s Medical Center were divided into group A (<0 05) and group B (0 0 5 ~ 0 2 5). Group B The patients were divided into three subgroups B1 (0 0 5 ~ 0 10), B2 (~ 0 15) and B3 (~ 0 2 5). The relationship between each group and the relapse of acute leukemia was analyzed. Results There was a significant difference between the control group and the percentage of naïve cells in CR of children with acute lymphoblastic leukemia (ALL) ≥0 10. The number of naïve cells in CR of children with acute non-lymphocytic leukemia (ANLL) ≥0.15 , The recurrence rate and the negative control group differences were significant. CONCLUSIONS: Primary lymphocytes + lymphocytes> 0 10 in bone marrow of children with CR after CR and primary myelocytic + promyelocytic or primitive mononuclear cells + young mononuclear cells ≥ 0 15 in bone marrow after CR should be considered Timely adjustment of treatment options.