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通过对２５例应用ＨＧＦ，１０例应用α－ＩＦＮ治疗的肝炎患者进行用药前后ＴＮＦ水平的检测，了解其作用机理。结果显示：ＨＧＦ治疗后肝炎患者血浆中ＴＮＦ含量明显低于治疗前（Ｐ＜０．０１），α－ＩＦＮ治疗后患者血清中ＴＮＦ水平较用药前明显升高（Ｐ＜０．０１），而４例未用上述二药者仅用一般保肝药治疗，其ＴＮＦ水平无显著变化（Ｐ＞０．０５），说明ＨＧＦ能调节细胞免疫，减少ＴＮＦ生成，α－ＩＦＮ治疗后ＴＮＦ水平升高，ＴＮＦ可能参与α－ＩＦＮ清除病毒过程。
Twenty-five patients with hepatitis treated with HGF and 10 patients treated with IFN-α were tested for TNF levels before and after treatment, and their mechanism of action was investigated. The results showed that the level of TNF in plasma of patients with HGF was significantly lower than that before treatment (P <0.01), and the level of TNF in serum of patients with α-IFN was significantly higher than that before treatment (P <0.01) 4 cases without the above two drugs only general hepatoprotective treatment, the TNF level was no significant change (P> 0.05), indicating that HGF can regulate cellular immunity, reduce TNF production, TNF-α after IFN-α treatment increased , TNF may be involved in α-IFN clearance virus process.