作者以3株二价冷重组甲型流感疫苗(CRA)和两株三价灭活流感疫苗(TI),对52名血清阴性的婴幼儿进行接种,观察反应原性和免疫原性。 作者于1985～1989年,选用52名健康婴幼儿作为研究对象。1985～1986年主要研究CRA的安全性。10名参试婴幼儿采用双盲安慰剂对照交叉法,即首先接种CRA疫苗或安慰剂者,2周后,疫苗接种者改用安慰剂,而安慰剂组则改用疫苗。1987～1988和1988～1989年则观察免疫原性。参试婴幼儿 In this study, 52 seronegative infants and young children were vaccinated with three strains of cold-adapted recombinant influenza A (CRA) vaccine and two trivalent inactivated influenza vaccines (TI) to observe the reactionogenicity and immunogenicity. Authors in 1985 ~ 1989, the selection of 52 healthy infants and young children as the research object. From 1985 to 1986, we studied the safety of CRA. The 10 participating infants were treated with a double-blind, placebo-controlled cross-treatment, first with a CRA vaccine or placebo, and two weeks later, the vaccine-to-placers were switched to vaccinated versus placebo. Immunogenicity was observed from 1987 to 1988 and from 1988 to 1989. Test infants