论文部分内容阅读
为研究血管紧张素原基因启动子区域 - 2 17、- 2 0位和 - 6位上的三种单核苷酸多态性与心肌梗死的相关性 ,采用多重SnaPshot反应 ,在中国南方汉人群中 ,对 2 16例心肌梗死患者和 185名健康对照者进行G 2 17A ,A 2 0C和G 6A多态基因分型。结果发现 ,G 2 17A多态AA、AG和GG基因型分布和A、G等位基因频率在心肌梗死组与对照组之间相比有显著性差异 (分别为 10、77、12 9比 8、37、14 0 ,P =0 .0 0 2 ;2 2 .4 5 %、77.5 5 %比 14 .32 %、85 .6 8% ,P=0 .0 0 3)。G 6A多态AA、AG和GG基因型分布在心肌梗死组和对照组之间亦有显著性差异 (分别为 14 7、6 4、5比12 7、4 4、14 ,P =0 .0 2 9) ,但A、G等位基因频率在两组间无显著性差异 (P =0 .394 )。A 2 0C多态CC、AC和AA基因型分布在两组间有差异 (分别为 6、5 1、15 9比 2、6 1、12 2 ) ,但无统计学意义 (P =0 .0 6 7) ,C、A等位基因频率在两组间亦无显著性差异 (P >0 .0 5 )。Logistic回归分析发现 ,年龄 (P =0 .0 0 1)、收缩压 (P =0 .0 13)和血浆甘油三酯浓度 (P =0 .0 10 )是该人群发生心肌梗死的独立危险因素 ,而高密度脂蛋白胆固醇 (P =0 .0 18)是一种保护因素。结果提示 ,在中国南方汉人群中 ,血管紧张素原基因G 2 17A和G 6A多态可能与心肌梗死的发生?
In order to investigate the relationship between three single nucleotide polymorphisms (SNPs) -217, -2 0 and -6 in the promoter region of angiotensinogen gene and myocardial infarction, multiple SnaPshot reactions were performed in Chinese Han population in southern China , G 2 17A, A 2 0C and G 6A polymorphism genotypes were performed on 216 patients with myocardial infarction and 185 healthy controls. The results showed that there was a significant difference in genotype distribution of G 2 17A AA, AG and GG genotypes and frequencies of A and G alleles between myocardial infarction group and control group (10, 77, 129, 8 , 37, 14 0, P = 0.002; 22.45%, 77.5 5% vs. 14.32%, 85.68%, P = .030). G 6A polymorphism AA, AG and GG genotype distribution between the myocardial infarction group and the control group also had significant differences (14 7,6 4,5 than 12 7,4 4,14, P = 0 .0 2 9). However, there was no significant difference in A and G allele frequencies between the two groups (P = .394). A20C polymorphic CC, AC, and AA genotypes differed between the two groups (6,5 1,15 9 vs 2,6 1,12 2, respectively), but not statistically significant (P = 0 .0 There was no significant difference between the two groups (P> 0.05). Logistic regression analysis showed that age (P = 0.010), systolic blood pressure (P = 0.013), and plasma triglyceride concentration (P = 0.010) were independent risk factors for myocardial infarction in this population , While high-density lipoprotein cholesterol (P = 0.018) was a protective factor. The results suggest that the G 2 17A and G 6A polymorphisms of the angiotensinogen gene may be associated with myocardial infarction in the Han Chinese population in southern China.