当一个有丝分裂细胞和一个分裂间期细胞融合时,产生染色体早熟浓集现象。早熟浓集染色体(PCC)的形态取决于融合时的分裂间期细胞的时相。在G_1早期、DNA 复制前,PCC 是长的单股;在G_2期,他们是由两个染色单体组成,仍比前期染色体长。在S 期,PCC 呈“粉碎”和“断片”状。已有报告在人类的胃癌、乳腺癌、卵巢癌、脑瘤、白血病和膀胱癌内观察到PCC。本文首次报导有关结 When a mitotic cell fuses with an interphase cell, chromosome precocity occurs. The morphology of precociously concentrated chromosomes (PCCs) depends on the phase of the interphase cells at the time of fusion. In the early stages of G 1 and before DNA replication, PCCs were long single strands; in G 2 they consisted of two chromatids and were still longer than the previous chromosomes. In the S phase, PCC was “smashed” and “fragmented”. PCC has been observed in human gastric cancer, breast cancer, ovarian cancer, brain tumor, leukemia and bladder cancer. This article first reported about the knot