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目的探讨脂蛋白脂酶的活性和早发冠心病患者临床表型之间的关系。方法收集我院冠心病患者100例为观察组,健康体检100例为对照组。采集空腹静脉血,分析脂蛋白脂酶活性和早发冠心病临床表型的关系。结果观察组的CRP及TG高于对照组,而LPL低于对照组,差异均有统计学意义(P<0.05)。实施多因素回归分析后显示LPL活性以及CRP有着高差值(P<0.05)。结论脂蛋白脂酶活性诸如CRP、TG以及LPL等和早发冠心病患者的各项临床表型均有明显关系,吸烟饮酒、高胆固醇以及高C-反应蛋白均为主要独立危险因素。
Objective To investigate the relationship between the activity of lipoprotein lipase and the clinical phenotype of patients with premature coronary heart disease. Methods 100 cases of coronary heart disease in our hospital were collected as observation group and 100 cases of healthy physical examination as control group. Fasting venous blood was collected for analysis of the relationship between lipoprotein lipase activity and the clinical phenotype of premature coronary artery disease. Results The CRP and TG in observation group were higher than those in control group, while LPL was lower than that in control group (P <0.05). Multivariate regression analysis showed that LPL activity and CRP had a high difference (P <0.05). Conclusions Lipoprotein lipase activity such as CRP, TG, LPL and so on are closely related to the clinical phenotypes of patients with premature coronary heart disease. Smoking and drinking, high cholesterol and high C-reactive protein are the main independent risk factors.