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蛋白激酶Ｃ(ＰＫＣ)参与正常肺血管张力的调控 ,低氧可使肺动脉ＰＫＣ蛋白水平表达增高 ,且可使ＰＫＣ对肺血管张力的调控作用明显增强。作者研究了低氧对肺动脉平滑肌细胞 (ＰＡＳＭＣ)在ｍＲＮＡ转录水平表达的影响以及ＰＫＣ对ＰＡＳＭＣ增殖的影响 ,发现慢性低氧动物肺动脉
Protein kinase C (PKC) is involved in the regulation of normal pulmonary vascular tone. Hypoxia can increase the expression of PKC in pulmonary artery, and can significantly enhance the regulation of PKC on pulmonary vascular tone. The authors studied the effects of hypoxia on the expression of pulmonary arterial smooth muscle cells (PASMCs) at the mRNA transcription level and the effect of PKC on the proliferation of PASMCs. We found that pulmonary hypoxia