论文部分内容阅读
心房颤动(房颤)的病因多认为是由心脏的组织结构及电活动的改变引起,近年来研究表明遗传因素也可能参与了房颤的发生:家族性房颤的遗传背景已较明确;非家族性房颤遗传因素的相关研究也取得了进展,其中肾素-血管紧张素-醛固酮系统基因多态性与房颤的相关性研究就取得了部分进展。有研究认为血管紧张素原基因多态性及血管紧张素转换酶基因多态性与房颤的发病有关,但也有相反观点;而血管紧张素受体基因多态性则多认为与房颤的发病无关;肾素和醛固酮合酶的基因多态性与房颤的相关性问题尚无明确报道。
The cause of atrial fibrillation (AF) is thought to be caused by changes in cardiac structure and electrical activity. In recent years, studies have shown that genetic factors may also be involved in the occurrence of atrial fibrillation: the genetic background of familial atrial fibrillation has been more clear; Progress has also been made in the study of genetic factors of familial atrial fibrillation, and some progress has been made in the study of the relationship between renin-angiotensin-aldosterone system gene polymorphism and atrial fibrillation. Some studies suggest that angiotensinogen gene polymorphism and angiotensin-converting enzyme gene polymorphisms and the pathogenesis of atrial fibrillation, but also have the opposite view; the angiotensin receptor gene polymorphism and more that with the atrial fibrillation The incidence of unrelated; renin and aldosterone synthase gene polymorphisms and the relationship between atrial fibrillation has not yet been clearly reported.