利用动物模型对肿瘤进行病因、病理以及治疗方法的研究是一个较好的方法。本世纪来不少学者使用化学致癌物在鼠、兔等动物身上致癌成功。1900年日本学者用煤焦油(Coal tar)成功地在兔耳上致成皮肤癌。1954年 Salley 在地鼠(Syrian hamster)口腔颊囊上涂用多环碳氢化合物产生鳞状细胞癌。10年前,Segaloff 用甲基胆蒽(methylcholanthrene)在 Fisher 344鼠上的前列腺上诱发的上皮癌移植到该鼠的头颈部不同区域,并传代下去。1982年 Ching- The use of animal models to study the etiology, pathology, and treatment of tumors is a good method. Many scholars have used chemical carcinogens to successfully carcinogenize animals such as rats and rabbits in this century. In 1900, Japanese scholars successfully used coal tar to cause skin cancer in rabbit ears. 1954 Salley smears polycyclic hydrocarbons on the oral cheek pouch of a Syrian hamster to produce squamous cell carcinoma. Ten years ago, Segaloff transplanted epithelial cancers that had been induced on the prostate gland of Fisher 344 mice with methylcholanthrene into different regions of the head and neck of the mice and passed them off. 1982 Ching-