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目的:观察去氧孕烯炔雌醇片治疗围绝经期功能性子宫出血的临床疗效。方法:72例围绝经期功能失调性子宫出血患者随机分为治疗组和对照组,治疗组在诊断性刮宫术后5 d给予去氧孕烯炔雌醇片治疗。对照组在诊断性刮宫术后5 d给予米非司酮治疗,B超检查子宫内膜厚度,观察不良反应,随访结束后评价临床疗效。结果:治疗组临床疗效总有效率为97.2%,显著高于对照组(93.3%),差异有统计学意义(P<0.05);治疗组控制出血时间和完全止血时间均低于对照组,差异有统计学意义(P<0.05);治疗后,治疗组子宫内膜厚度(5.69±0.72)mm,对照组(7.91±0.35)mm,两者比较差异有统计学意义(P<0.05);2组不良反应轻微。结论:去氧孕烯炔雌醇片治疗围绝经期功能失调性子宫出血临床疗效显著,安全可靠,值得临床推广应用。
Objective: To observe the clinical effect of deoxygestrel ethinyl estradiol tablets in treating peri-menopausal dysfunctional uterine bleeding. Methods: Seventy-two patients with dysfunctional uterine bleeding in peri-menopausal period were randomly divided into treatment group and control group. The treatment group was treated with desogestrel ethinyl estradiol 5 days after the diagnostic curettage. The control group was treated with mifepristone 5 days after diagnostic curettage, the thickness of endometrium was examined by B ultrasound, and the adverse reaction was observed. After the follow-up, the clinical effect was evaluated. Results: The total effective rate of the treatment group was 97.2%, which was significantly higher than that of the control group (93.3%), the difference was statistically significant (P <0.05); the control bleeding time and complete bleeding time were lower in the treatment group than in the control group, (P <0.05). After treatment, the thickness of the endometrium in the treatment group was (5.69 ± 0.72) mm and in the control group (7.91 ± 0.35) mm, the difference was statistically significant (P <0.05); 2 Adverse reactions were mild. Conclusion: The clinical efficacy of DES in treating peri-menopausal dysfunctional uterine bleeding is significant, safe and reliable, which is worthy of clinical application.