目的观察干扰素的抗病毒作用。方法用天然多亚型干扰素－αＮ１（惠福仁）治疗５０例慢性乙型肝炎，另５０例为对照组，两组临床与实验室指标均有可比性。治疗组用ＩＦＮ－αＮ１３ＭｕＩＭｑｄ治疗７ｄ，继用３ＭｕＩＭｔｉｗ治疗１１～２３周。结果经３个月治疗，治疗组与对照组的丙氨酸转氨酶复常率分别为８４％（４２５０）和４６％（２３５０），Ｐ＜０．０１；ＨＢｅＡｇ阴转率为５６．７％（１７３０）和１０．８％（４３７）；ＨＢＶＤＮＡ的阴转率为３６．４％（１２３３）和５．９％（１１７），Ｐ＜０．０１。结论ＩＦＮ－αＮ１治疗慢性乙型肝炎是目前疗效比较满意的抗病毒药，且副作用少，适于对其他干扰素疗效不佳的病例 Objective To observe the antiviral effect of interferon. Methods Fifty patients with chronic hepatitis B were treated with natural multi-subtype interferon-αN1 (Huifu Ren) and the other 50 patients as control group. The clinical and laboratory indexes of the two groups were comparable. The treatment group with IFN-αN13MuIMqd treatment 7d, followed by 3MuIMtiw treatment for 11 to 23 weeks. Results After 3 months of treatment, the normalization rates of alanine aminotransferase in treatment group and control group were 84% (4250) and 46% (2350) respectively, P <0.01; the negative conversion rate of HBeAg was 56 .7% (1730) and 10.8% (437) respectively. The negative conversion rates of HBVDNA were 36.4% (1233) and 5.9% (117), P <0.01 . Conclusion IFN-αN1 treatment of chronic hepatitis B is currently relatively satisfactory anti-viral drugs, and less side effects, suitable for other cases of poor efficacy of interferon