纳络酮(naloxone)是内源性阿片样物质的特异性拮抗剂,它的临床用途近年来有新的发展。值得注意的是,它对酒精中毒、休克、脑缺血性中风、垂体激素分泌亢进综合征、精神分裂症及先天性无痛症等的疗效。纳络酮对各型阿片受体亚型均有拮抗作用,无前驱或后继的激动作用;对阿片受体亲和力大于吗啡或脑啡肽。本品静注后生效快, Naloxone is a specific antagonist of endogenous opioids, and its clinical use has undergone a new development in recent years. It is worth noting that it has effects on alcoholism, shock, ischemic stroke, pituitary hormone syndrome, schizophrenia and congenital painlessness. Naloxone has antagonistic effects on all kinds of opioid receptor subtypes, no prodromal or subsequent agonism; the affinity for opioid receptors is greater than that of morphine or enkephalin. This product is effective after intravenous injection,